Just this past week, the US Food and Drug Administration (FDA) approved an antibiotic called secnidazole (Solosec, Symbiomix Therapeutics) for treatment of bacterial vaginosis in women.
Bacterial vaginosis(BV) is the most common vaginal infection in women between the ages of 15 to 44 years, according to the Centers for Disease Control and Prevention.
A dose of Solosec is a 2-g packet of granules. It is sprinkled on applesauce, yogurt, or pudding and eaten within 30 minutes without chewing or crunching the granules.
Most current antibiotics treatments for bacterial vaginosis must be taken for 5 to 7 days, and often 2-3 times a day. Taking a single-dose of Solosec helps to improve compliance and the likelihood of a cure, Symbiomix Therapeutics stated in a news release.
The FDA approved Solosec based on two randomized, placebo-controlled clinical trials involving 333 nonpregnant women up to age 54 years.
The most common adverse events seen in the two studies were vulvovaginal candidiasis, headache, nausea,An alteration in taste, vomiting, and diarrhea. There is a warning on the label that says vulvovaginal candidiasis associated with the use of Solosec may require treatment with an antifungal drug.
Solosec is not recommended for women who are breast-feeding. If a nursing mother takes Solosec, she should discontinue breast-feeding for 96 hours afterward. Patients are also advised to avoid chronic use.In addition to taking antibiotics for BV, it is recommended to take a potent Probiotic to replace the “good” bacteria in the vagina and prevent further infections due to overgrowth of other bacteria or yeast.